Open AccessDestabilization of Simple Repetitive DNA Sequences by Transcription in Yeast
Author(s) -
Monika Wierdl,
Christopher N. Greene,
Abhijit Datta,
Sue Jinks-Robertson,
Thomas D. Petes
Publication year - 1996
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/143.2.713
Subject(s) - biology , repeated sequence , transcription (linguistics) , genetics , dna , yeast , genome , saccharomyces cerevisiae , gene , linguistics , philosophy
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
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