Effects of Single P-Element Insertions on Olfactory Behavior in Drosophila melanogaster | Zendy

Robert R. H. Anholt | Zendy; Richard F. Lyman | Zendy; Trudy F. C. Mackay | Zendy

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Effects of Single P-Element Insertions on Olfactory Behavior in Drosophila melanogaster

Author(s) -

Robert R. H. Anholt,

Richard F. Lyman,

Trudy F. C. Mackay

Publication year - 1996

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/143.1.293

Subject(s) - biology , drosophila melanogaster , p element , enhancer , genetics , insertional mutagenesis , enhancer trap , drosophilidae , gene , dna transposable elements , olfaction , mutagenesis , transposable element , gene expression , mutation , neuroscience , genome

Single P-element (P[lArB]) insertional mutagenesis of an isogenic strain was used to identify autosomal loci affecting odor-guided behavior of Drosophila melanogaster. The avoidance response to benzaldehyde of 379 homozygous P[lArB] element-containing insert lines was evaluated quantitatively. Fourteen smell impaired (smi) lines were identified in which P[lArB] element insertion caused different degrees of hyposmia in one or both sexes. The smi loci map to different cytological locations and probably are novel olfactory genes. Enhancer trap analysis of the smi lines indicates that expression of at least 10 smi genes is controlled by olfactory tissue-specific promoter/enhancer elements.

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