Involvement of a replicative DNA helicase of bacteriophage T4 in DNA recombination. | Zendy

Tetsuro Yonesaki | Zendy

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Involvement of a replicative DNA helicase of bacteriophage T4 in DNA recombination.

Author(s) -

Tetsuro Yonesaki

Publication year - 1994

Publication title -

genetics.

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

ISSN - 3049-7094

DOI - 10.1093/genetics/138.2.247

Subject(s) - biology , genetics , dna replication , helicase , bacteriophage , dna , prokaryotic dna replication , mutation , microbiology and biotechnology , gene , control of chromosome duplication , rna helicase a , homologous recombination , genetic recombination , dna polymerase , recombination , escherichia coli , rna

Bacteriophage T4 gene 41 encodes a replicative DNA helicase that is a subunit of the primosome which is essential for lagging-strand DNA synthesis. A mutation, rrh, was generated and selected in the helicase gene on the basis of limited DNA replication that ceases early. The survival of ultraviolet-irradiated phage and the frequency of genetic recombination are reduced by rrh. In addition, rrh diminishes the production of concatemeric DNA. These results strongly suggest that the gene 41 replicative helicase participates in DNA recombination.

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