The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. | Zendy

M J Palmer | Zendy; V A Mergner | Zendy; R Richman | Zendy; Jerry E. Manning | Zendy; Mitzi I. Kuroda | Zendy; John C. Lucchesi | Zendy

Open Access

The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males.

Author(s) -

M J Palmer,

V A Mergner,

R Richman,

Jerry E. Manning,

Mitzi I. Kuroda,

John C. Lucchesi

Publication year - 1993

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/134.2.545

Subject(s) - dosage compensation , biology , drosophila melanogaster , gene , genetics , chromatin , x chromosome , transcription (linguistics) , chromosome , nuclear protein , lethal allele , transcription factor , linguistics , philosophy

Male-specific lethal-one (msl-1) is one of four genes that are required for dosage compensation in Drosophila males. To determine the molecular basis of msl-1 regulation of dosage compensation, we have cloned the gene and characterized its products. The predicted msl-1 protein (MSL-1) has no significant similarity to proteins in the current data bases but contains an acidic N terminus characteristic of proteins involved in transcription and chromatin modeling. We present evidence that the msl-1 protein is associated with hundreds of sites along the length of the X chromosome in male, but not in female, nuclei. Our findings support the hypothesis that msl-1 plays a direct role in increasing the level of X-linked gene transcription in male nuclei.

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