Post-transcriptional regulation of RNA polymerase II levels in Caenorhabditis elegans. | Zendy

Brian K. Dalley | Zendy; T M Rogalski | Zendy; Gregory E. Tullis | Zendy; Donald L Riddle | Zendy; Miriam Golomb | Zendy

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Post-transcriptional regulation of RNA polymerase II levels in Caenorhabditis elegans.

Author(s) -

Brian K. Dalley,

T M Rogalski,

Gregory E. Tullis,

Donald L Riddle,

Miriam Golomb

Publication year - 1993

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/133.2.237

Subject(s) - biology , rna polymerase , caenorhabditis elegans , polymerase , rna polymerase ii , rna , gene , microbiology and biotechnology , genetics , rna polymerase i , dosage compensation , rna dependent rna polymerase , transcription (linguistics) , gene expression , promoter , linguistics , philosophy

To investigate the regulation of RNA polymerase II levels in Caenorhabditis elegans, we have constructed nematode strains having one, two, or three copies of ama-1, the gene for the largest subunit of RNA polymerase II. Steady-state levels of RNA polymerase II polypeptides and solubilized enzyme activity are invariant with gene dosage, indicating regulatory compensation. However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage. These results imply that RNA polymerase II levels in C. elegans are regulated post-transcriptionally.

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