Increased variation in ADH enzyme activity in Drosophila mutation-accumulation experiment is not due to transposable elements at the Adh structural gene. | Zendy

Charles F. Aquadro | Zendy; Hidenori Tachida | Zendy; Charles H. Langley | Zendy; Ko Harada | Zendy; Terumi Mukai | Zendy

Open Access

Increased variation in ADH enzyme activity in Drosophila mutation-accumulation experiment is not due to transposable elements at the Adh structural gene.

Author(s) -

Charles F. Aquadro,

Hidenori Tachida,

Charles H. Langley,

Ko Harada,

Terumi Mukai

Publication year - 1990

Publication title -

genetics.

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

ISSN - 3049-7094

DOI - 10.1093/genetics/126.4.915

Subject(s) - biology , transposable element , alcohol dehydrogenase , genetics , gene , drosophila melanogaster , structural gene , allele , mutation , structural variation , enzyme , mutant , biochemistry , genome

We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity compared to control lines, we found no restriction map variation in a 13-kb region including the complete Adh structural gene and roughly 5 kb of both 5' and 3' sequences. Thus, the rapid accumulation of ADH activity variation after 28,200 allele generations does not appear to have been due to the mobilization of transposable elements into or out of the Adh structural gene region.

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