Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster. | Zendy

Léonard Rabinow | Zendy; James A. Birchler | Zendy

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Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster.

Author(s) -

Léonard Rabinow,

James A. Birchler

Publication year - 1990

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/125.1.41

Subject(s) - biology , drosophila melanogaster , notch signaling pathway , locus (genetics) , genetics , cell fate determination , phenotype , allele , cellular differentiation , gene , microbiology and biotechnology , transcription factor

Interactions are described between the Notch locus of Drosophila melanogaster, and two other loci, scabrous and vestigial, which respectively affect the eyes and wings. The Notch locus is responsible for mediating decisions of cell fate throughout development in many different tissues. Mutations and duplications of vestigial and scabrous alter the severity of phenotypes associated with Notch mutations and duplications in a manner that is essentially tissue- and allele-specific. These interactions indicate that the products of vestigial and scabrous act in conjunction with Notch to stimulate the differentiation of specific cell types.

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