The effect of change in population size on DNA polymorphism. | Zendy

Fumio Tajima | Zendy

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The effect of change in population size on DNA polymorphism.

Author(s) -

Fumio Tajima

Publication year - 1989

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/123.3.597

Subject(s) - biology , genetics , population size , population , effective population size , bottleneck , single nucleotide polymorphism , population bottleneck , nucleotide , genetic variation , gene , allele , genotype , demography , microsatellite , sociology , computer science , embedded system

The expected number of segregating sites and the expectation of the average number of nucleotide differences among DNA sequences randomly sampled from a population, which is not in equilibrium, have been developed. The results obtained indicate that, in the case where the population size has changed drastically, the number of segregating sites is influenced by the size of the current population more strongly than is the average number of nucleotide differences, while the average number of nucleotide differences is affected by the size of the original population more severely than is the number of segregating sites. The results also indicate that the average number of nucleotide differences is affected by a population bottleneck more strongly than is the number of segregating sites.

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