Xanthine dehydrogenase is transported to the Drosophila eye. | Zendy

Andrew G. Reaume | Zendy; Stephen H. Clark | Zendy; Arthur Chovnick | Zendy

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Xanthine dehydrogenase is transported to the Drosophila eye.

Author(s) -

Andrew G. Reaume,

Stephen H. Clark,

Arthur Chovnick

Publication year - 1989

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/123.3.503

Subject(s) - xanthine dehydrogenase , biology , drosophila melanogaster , peroxisome , enzyme , genetics , mutant , locus (genetics) , biochemistry , phenotype , gene , xanthine oxidase

The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a deficiency in the red eye pigment. This report demonstrates that enzyme which is synthesized in some tissue other than the eye is transported and sequestered at the eye. Previous studies find that no leader sequence is associated with this molecule but a peroxisomal targeting sequence has been noted, and the enzyme has been localized to peroxisomes. This represents a rare example of an enzyme involved in intermediary metabolism being transported from one tissue to another and may also be the first example of a peroxisomal protein being secreted from a cell.

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