On measures of gametic disequilibrium. | Zendy

Richard C Lewontin | Zendy

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On measures of gametic disequilibrium.

Author(s) -

Richard C Lewontin

Publication year - 1988

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/120.3.849

Subject(s) - disequilibrium , allele , biology , linkage disequilibrium , genetics , measure (data warehouse) , allele frequency , association (psychology) , genetic association , genotype , gene , haplotype , computer science , single nucleotide polymorphism , medicine , database , ophthalmology , philosophy , epistemology

Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the same range for all allelic frequencies, in fact, D' is not "independent" of allele frequency, and no measure with that general property is possible for the multilocus association problem. The insolubility of this problem arises from the ill-defined nature of general "association."

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