REPRESSION OF MEIOTIC CROSSING OVER BY A CENTROMERE (CEN3) IN SACCHAROMYCES CEREVISIAE | Zendy

Eric J. Lambie | Zendy; G. Shirleen Roeder | Zendy

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REPRESSION OF MEIOTIC CROSSING OVER BY A CENTROMERE (CEN3) IN SACCHAROMYCES CEREVISIAE

Author(s) -

Eric J. Lambie,

G. Shirleen Roeder

Publication year - 1986

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/114.3.769

Subject(s) - centromere , saccharomyces cerevisiae , meiosis , biology , genetics , chromosomal crossover , chromosome , transformation (genetics) , yeast , gene

The location of the centromere of chromosome III (CEN3) of Saccharomyces cerevisiae has been altered by means of transformation. The frequency of meiotic crossing over in the CEN3-PGK1 and LEU2-CEN3 intervals increases approximately 1.5- and fourfold, respectively, when CEN3 is repositioned at HIS4. The centromere-distal HIS4-LEU2 region experiences a three- to fivefold decrease in the frequency of meiotic exchange when CEN3 is repositioned at HIS4. The inhibition of meiotic crossing over is conferred by a 627-base-pair fragment of CEN3 DNA and is not dependent on the orientation of CEN3 relative to the rest of chromosome III.

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