FRAMESHIFT SUPPRESSION BY thyA MUTANTS OF ESCHERICHIA COLI K-12 | Zendy

Muriel B. Herrington | Zendy; Anjali Kohli | Zendy; Maria Faraci | Zendy

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FRAMESHIFT SUPPRESSION BY thyA MUTANTS OF ESCHERICHIA COLI K-12

Author(s) -

Muriel B. Herrington,

Anjali Kohli,

Maria Faraci

Publication year - 1986

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/114.3.705

Subject(s) - frameshift mutation , biology , mutant , genetics , escherichia coli , mutation , microbiology and biotechnology , nonsense mutation , gene , missense mutation

We have extended our previous study on the suppression of frameshift mutants by Escherichia coli thyA mutants by assaying suppression of 15 rIIB frameshift mutants of bacteriophage T4 on one of our suppressing thyA mutant strains. The majority of insertion mutants were suppressible, whereas none of the deletion mutants tested was suppressible. Frameshift suppression could be inhibited by adding thymidine to the assay medium, but was not affected by the presence of a restrictive rpsL mutation in the host strain. We suggest that the frameshift suppression event occurs at a nonsense codon generated by the frameshift mutation.

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