EVIDENCE FOR EVOLUTIONARY DUPLICATION OF GENES IN THE DOPA DECARBOXYLASE REGION OF DROSOPHILA | Zendy

David D Eveleth | Zendy; J. Lawrence Marsh | Zendy

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EVIDENCE FOR EVOLUTIONARY DUPLICATION OF GENES IN THE DOPA DECARBOXYLASE REGION OF DROSOPHILA

Author(s) -

David D Eveleth,

J. Lawrence Marsh

Publication year - 1986

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/114.2.469

Subject(s) - gene duplication , biology , gene , gene cluster , genetics , functional divergence , aromatic l amino acid decarboxylase , homology (biology) , gene family , gene expression , enzyme , biochemistry

The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the products of a gene duplication event. The two genes are transcribed convergently and are separated by 2.4 kb. A gene located between Ddc and amd expresses a 2.0-kb mRNA and appears to partially overlap the Ddc gene. The organization of these transcripts implies a complex series of events giving rise to the present pattern. The patterns of expression of these genes do not support a model of coordinate regulation, but are more consistent with a pattern of duplication and divergence to various related metabolic subspecialties. These data provide the first evidence for structural relationships among genes in the 37C cluster.

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