COMPLEX CIS-ACTING REGULATORS AND LOCUS STRUCTURE OF DROSOPHILA TISSUE-SPECIFIC ADH VARIANTS | Zendy

Léonard Rabinow | Zendy; William J. Dickinson | Zendy

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COMPLEX CIS-ACTING REGULATORS AND LOCUS STRUCTURE OF DROSOPHILA TISSUE-SPECIFIC ADH VARIANTS

Author(s) -

Léonard Rabinow,

William J. Dickinson

Publication year - 1986

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/112.3.523

Subject(s) - biology , locus (genetics) , genetics , alcohol dehydrogenase , drosophila (subgenus) , drosophilidae , gene , drosophila melanogaster , enzyme , biochemistry

Diverse patterns of tissue-specific expression of alcohol dehydrogenase (ADH) among species of the grimshawi subgroup of Hawaiian picture-winged Drosophila suggests control by complex or multiple, independently acting regulatory elements. These elements act by controlling Adh mRNA accumulation in individual tissue types. Restriction mapping of the Adh loci from these species reveals several insertion/deletion differences, one of which lies just outside the 5' end of the structural sequences and correlates with differences in larval patterns of ADH expression. No tissue-specific rearrangement of Adh sequences was observed.

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