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When recently arisen spontaneous petite mutants of Saccharomyces cerevisiae are crossed, respiratory competent diploids can be recovered. Such restored strains can be divided into two groups having sectored or unsectored colony morphology, the former being due to an elevated level of spontaneous petite mutation. On the basis of petite frequency, the sectored strains can be subdivided into those with a moderate frequency (5-16%) and those with a high frequency (&amp;gt;60%) of petite formation. Each of the three categories of restored strains can be found on crossing two petites, suggesting either that the parental mutants contain a heterogeneous population of deleted mtDNAs at the time of mating or that different interactions can occur between the defective molecules. Restriction endonuclease analysis of mtDNA from restored strains that have a wild-type petite frequency showed that they had recovered a wild-type mtDNA fragmentation pattern. Conversely, all examined cultures from both categories of sectored strains contained aberrant mitochondrial genomes that were perpetuated without change over at least 200 generations. In addition, sectored colony siblings can have different aberrant mtDNAs. The finding that two sectored, restored strains from different crosses have identical but aberrant mtDNAs provides evidence for preferred deletion sites from the mitochondrial genome. Although it appears that mtDNAs from sectored strains invariably contain duplications, there is no apparent correlation between the size of the duplication and spontaneous petite frequency.

genetics

ELEVATED LEVELS OF PETITE FORMATION IN STRAINS OF <i>SACCHAROMYCES CEREVISIAE</i> RESTORED TO RESPIRATORY COMPETENCE. I. ASSOCIATION OF BOTH HIGH AND MODERATE FREQUENCIES OF PETITE MUTANT FORMATION WITH THE PRESENCE OF ABERRANT MITOCHONDRIAL DNA

ELEVATED LEVELS OF PETITE FORMATION IN STRAINS OF SACCHAROMYCES CEREVISIAE RESTORED TO RESPIRATORY COMPETENCE. I. ASSOCIATION OF BOTH HIGH AND MODERATE FREQUENCIES OF PETITE MUTANT FORMATION WITH THE PRESENCE OF ABERRANT MITOCHONDRIAL DNA