SELECTION COMPONENTS IN BACKGROUND REPLACEMENT LINES OF DROSOPHILA | Zendy

Andrew G. Clark | Zendy; Jørgen Bundgaard | Zendy

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SELECTION COMPONENTS IN BACKGROUND REPLACEMENT LINES OF DROSOPHILA

Author(s) -

Andrew G. Clark,

Jørgen Bundgaard

Publication year - 1984

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/108.1.181

Subject(s) - biology , backcrossing , genetics , drosophila melanogaster , linkage disequilibrium , locus (genetics) , selection (genetic algorithm) , natural selection , background selection , evolutionary biology , allele , haplotype , gene , artificial intelligence , computer science

Selection components analysis was performed in lines of Drosophila melanogaster at three times during substitution backcrossing. The initial two lines were inbred isofemale lines from natural populations in California, and one had the spread wing mutation eagle. The selection components analysis revealed aspects of the genetic structure of the determinants of fitness by demonstrating changes in the marginal fitnesses of the eagle locus. Differences among backgrounds essentially disappeared by the 20th generation of backcrossing, suggesting that the previously observed differences were attributable to linkage disequilibrium. The method of bootstrapping was used as a novel means of determining statistical confidence in selection components.

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