COINCIDENT GENE CONVERSION DURING MITOSIS IN SACCHAROMYCES | Zendy

John Golin | Zendy; Michael S. Esposito | Zendy

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COINCIDENT GENE CONVERSION DURING MITOSIS IN SACCHAROMYCES

Author(s) -

John Golin,

Michael S. Esposito

Publication year - 1984

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/107.3.355

Subject(s) - gene conversion , locus (genetics) , genetics , biology , mitosis , mitotic crossover , recombination , saccharomyces cerevisiae , gene , chromosome , genetic recombination

During mitosis, gene conversion events at the TRP5 locus on chromosome VII are coupled with conversion events at LEU1, a locus 18 cM away, 1200 times more frequently than would be expected for two independent acts of recombination. Such coincident conversion events that occur over relatively long distances could be due to several mechanisms. We discuss these possibilities and describe an experiment that indicates that a portion of coincident events is due to extensive heteroduplexes. The phenomenon of coincident gene conversion is discussed in relation to our earlier evidence that spontaneous recombination between homologues occurs prereplicationally in mitosis.

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