PLEIOTROPIC OVERDOMINANCE AND THE MAINTENANCE OF GENETIC VARIATION IN POLYGENIC CHARACTERS | Zendy

John H. Gillespie | Zendy

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PLEIOTROPIC OVERDOMINANCE AND THE MAINTENANCE OF GENETIC VARIATION IN POLYGENIC CHARACTERS

Author(s) -

John H. Gillespie

Publication year - 1984

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/107.2.321

Subject(s) - overdominance , biology , selection (genetic algorithm) , genetics , loss of heterozygosity , phenotype , mutation , evolutionary biology , balancing selection , genetic variation , genetic model , stabilizing selection , heterozygote advantage , variation (astronomy) , allele , gene , artificial intelligence , computer science , physics , astrophysics

A model of selection is described in which optimizing phenotypic selection is combined with pleiotropic overdominance. Thus, the role that mutation commonly plays in models of phenotypic evolution is replaced by balancing selection. Expressions are provided for the equilibrium genetic variance in phenotype and for the heterozygosity. An approximate analysis of the transient properties of the model shows that, in certain circumstances, the behavior is quite similar to that of models based on the interaction of mutation and selection.

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