EVIDENCE FOR BALANCING SELECTION AT HLA | Zendy

Philip W. Hedrick | Zendy; Glenys Thomson | Zendy

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EVIDENCE FOR BALANCING SELECTION AT HLA

Author(s) -

Philip W. Hedrick,

Glenys Thomson

Publication year - 1983

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/104.3.449

Subject(s) - biology , balancing selection , selection (genetic algorithm) , genetics , neutrality , human leukocyte antigen , evolutionary biology , allele , gene , computer science , philosophy , epistemology , artificial intelligence , antigen

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

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