INVOLVEMENT OF GENE 49 IN RECOMBINATION OF BACTERIOPHAGE T4 | Zendy

Junichi Miyazaki | Zendy; Yeikou Ryo | Zendy; Teiichi Minagawa | Zendy

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INVOLVEMENT OF GENE 49 IN RECOMBINATION OF BACTERIOPHAGE T4

Author(s) -

Junichi Miyazaki,

Yeikou Ryo,

Teiichi Minagawa

Publication year - 1983

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/104.1.1

Subject(s) - biology , mutant , recombination , gene , genetics , microbiology and biotechnology , mutation , genetic recombination , recombinant dna , bacteriophage , dna , escherichia coli

The role of T4 gene 49 in recombination was investigated using its conditional-lethal amber (am) and temperature-sensitive (ts) mutants. When measured in genetic tests, defects in gene 49 produced a recombination-deficient phenotype. However, DNA synthesized in cells infected with a ts mutant (tsC9) at a nonpermissive temperature appeared to be in a recombinogenic state: after restitution of gene function by shifting to a permissive temperature, the recombinant frequency among progeny increased rapidly even when DNA replication was blocked by an inhibitor. Growth of a gene 49-defective mutant was suppressed by an additional mutation in gene uvsX, but recombination between rII markers was not.

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