DOSAGE COMPENSATION IN DROSOPHILA: NADP-ENZYME ACTIVITIES AND CROSS-REACTING MATERIAL | Zendy

John H. Williamson | Zendy; Michael M. Bentley | Zendy

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DOSAGE COMPENSATION IN DROSOPHILA: NADP-ENZYME ACTIVITIES AND CROSS-REACTING MATERIAL

Author(s) -

John H. Williamson,

Michael M. Bentley

Publication year - 1983

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/103.4.649

Subject(s) - biology , gene , gene duplication , dosage compensation , genetics , enzyme , malic enzyme , enzyme assay , chromosome , gene dosage , x chromosome , activator (genetics) , genotype , biochemistry , gene expression , dehydrogenase

The relationships between gene dosage, enzyme activities and CRM levels have been determined for G6PD and 6PGD. Enzyme activities and CRM levels were directly proportional and increased in genotypes carrying duplications of the respective structural genes. When a duplication consisting of the distal 45% of the X chromosome was used to duplicate Pgd+, 6PGD activity and CRM increased and G6PD activity decreased. When the proximal 55% of the X chromosome was duplicated, G6PD activity and CRM increased whereas 6PGD activity and CRM levels decreased. These observations support the model of dosage compensation of X-linked genes that invokes an autosomal activator in limited concentrations for which X-linked loci compete. The distal 45% of the X chromosome, when duplicated, caused a significant increase in NADP-malic enzyme activity and CRM levels, as if a structural gene for NADP-ME is sex-linked.

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