FRAMESHIFT SUPPRESSION IN SACCHAROMYCES CEREVISIAE VI. COMPLETE GENETIC MAP OF TWENTY-FIVE SUPPRESSOR GENES | Zendy

Richard F. Gaber | Zendy; Lorilee Mathison | Zendy; Irv Edelman | Zendy; Michael R. Culbertson | Zendy

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FRAMESHIFT SUPPRESSION IN SACCHAROMYCES CEREVISIAE VI. COMPLETE GENETIC MAP OF TWENTY-FIVE SUPPRESSOR GENES

Author(s) -

Richard F. Gaber,

Lorilee Mathison,

Irv Edelman,

Michael R. Culbertson

Publication year - 1983

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/103.3.389

Subject(s) - frameshift mutation , genetics , biology , gene , suppressor , saccharomyces cerevisiae , genome , gene mapping , chromosome , mutation

Five previously unmapped frameshift suppressor genes have been located on the yeast genetic map. In addition, we have further characterized the map positions of two suppressors whose approximate locations were determined in an earlier study. These results represent the completion of genetic mapping studies on all 25 of the known frameshift suppressor genes in yeast.—The approximate location of each suppressor gene was initially determined through the use of a set of mapping strains containing 61 signal markers distributed throughout the yeast genome. Standard meiotic linkage was assayed in crosses between strains carrying the suppressors and the mapping strains. Subsequent to these approximate linkage determinations, each suppressor gene was more precisely located in multi-point crosses. The implications of these mapping results for the genomic distribution of frameshift suppressor genes, which include both glycine and proline tRNA genes, are discussed.

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