CIS-TRANS EFFECTS INDUCED BY LINKAGE DISEQUILIBRIUM | Zendy

Michael Turelli | Zendy

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CIS-TRANS EFFECTS INDUCED BY LINKAGE DISEQUILIBRIUM

Author(s) -

Michael Turelli

Publication year - 1982

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/102.4.807

Subject(s) - linkage disequilibrium , biology , genetics , linkage (software) , disequilibrium , trait , phenotype , character (mathematics) , genotype , genetic linkage , heterozygote advantage , evolutionary biology , gene , single nucleotide polymorphism , medicine , geometry , mathematics , ophthalmology , computer science , programming language

This note concerns theoretical and experimental studies of multifactorial traits, especially fitness and its components, in which (1) the loci studied are only a subset of those relevant to the character of interest and (2) the genotypes at the loci studied are in nonrandom association (linkage disequilibrium) with genotypes at the loci ignored. In these cases, phenotypic differences between cis and trans double heterozygotes can occur even though no linkage phase effects are inherent in the genetic determination of the trait. Examples are drawn from both theoretical and experimental work, and implications in both areas are discussed.

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