PEP4 GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN SACCHAROMYCES CEREVISIAE | Zendy

Elizabeth W. Jones | Zendy; George S. Zubenko | Zendy; Roy Parker | Zendy

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PEP4 GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN SACCHAROMYCES CEREVISIAE

Author(s) -

Elizabeth W. Jones,

George S. Zubenko,

Roy Parker

Publication year - 1982

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/102.4.665

Subject(s) - vacuole , saccharomyces cerevisiae , biology , mutation , gene , yeast , enzyme , locus (genetics) , biochemistry , rnase p , glycoprotein , structural gene , microbiology and biotechnology , genetics , cytoplasm , rna , escherichia coli

The pep4-3 mutation results in a 90-95% reduction in the levels of five vacuolar hydrolases in yeast, including proteinases A and B, carboxypeptidase Y, RNase(s) and the repressible alkaline phosphatase. The mutation is without effect on two secreted glycoproteins, on an enzyme of the vacuolar membrane, and on a proteinase located outside of the vacuole. Mutations at the PEP4 locus exhibit a dosage effect on the levels of some, but not all, of the enzymes whose expression requires the function of the gene.

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