DOSAGE COMPENSATION OF SERINE-4 TRANSFER RNA IN DROSOPHILA MELANOGASTER | Zendy

James A. Birchler | Zendy; R.K. Owenby | Zendy; K. Bruce Jacobson | Zendy

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DOSAGE COMPENSATION OF SERINE-4 TRANSFER RNA IN DROSOPHILA MELANOGASTER

Author(s) -

James A. Birchler,

R.K. Owenby,

K. Bruce Jacobson

Publication year - 1982

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/102.3.525

Subject(s) - drosophila melanogaster , biology , dosage compensation , genetics , drosophila (subgenus) , serine , compensation (psychology) , gene , x chromosome , phosphorylation , psychology , psychoanalysis

A dosage series of the X chromosome site for serine-4 transfer RNA consisting of one of three copies in females and one to two in males was constructed to test whether transfer RNA expression is governed by dosage compensation. A dosage effect on the level of the serine-4 isoacceptor was observed in both females and males when the structural locus was varied. However, in males, each dose had a relatively greater expression so the normal one dose was slightly greater than the total female value and the duplicated male had the highest relative expression of all the types examined. Serine-4 levels in males and females from an isogenic Oregon-R stock was similar. Thus the transfer RNA levels conform to the expectations of dosage compensation.

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