PROPERTIES AND EVOLUTIONARY POTENTIAL OF NEWLY INDUCED TANDEM DUPLICATIONS IN DROSOPHILA MELANOGASTER | Zendy

Paul Roberts | Zendy; David Broderick | Zendy

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PROPERTIES AND EVOLUTIONARY POTENTIAL OF NEWLY INDUCED TANDEM DUPLICATIONS IN DROSOPHILA MELANOGASTER

Author(s) -

Paul Roberts,

David Broderick

Publication year - 1982

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/102.1.75

Subject(s) - tandem exon duplication , biology , polytene chromosome , genetics , drosophila melanogaster , gene duplication , tandem , linkage disequilibrium , crossover , somatic cell , evolutionary biology , gene , allele , haplotype , materials science , artificial intelligence , computer science , composite material

Most of some 33 X-ray-induced duplications recovered as Suppressors of Minute loci proved to be direct tandem duplications. When heterozygous, most duplications were crossover suppressors, and duplications of short to moderate size did not reduce the fitness of their bearers. Crossover suppression by tandem duplication may be attributed to intrastrand foldbacks of the type regularly seen in somatic polytene chromosomes. As a consequence, linkage disequilibrium between duplicated elements and normal chromosomes should be more profound than has been supposed. Tandem duplications appear to be predisposed by reason of frequency of generation, crossover suppression and fitness effects to serve as the primary source of new genes.

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