SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution | Zendy

Zackery E. Plyler | Zendy; Aubrey E. Hill | Zendy; Christopher W. McAtee | Zendy; Xiangqin Cui | Zendy; Leah A. Moseley | Zendy; Eric J. Sorscher | Zendy

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SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution

Author(s) -

Zackery E. Plyler,

Aubrey E. Hill,

Christopher W. McAtee,

Xiangqin Cui,

Leah A. Moseley,

Eric J. Sorscher

Publication year - 2015

Publication title -

genome biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.702

H-Index - 74

ISSN - 1759-6653

DOI - 10.1093/gbe/evv150

Subject(s) - biology , genetics , genome , intergenic region , indel , single nucleotide polymorphism , negative selection , snp , sanger sequencing , gene , genomic dna , noncoding dna , molecular inversion probe , dna , human genome , mutagenesis , computational biology , mutation , genotype

In this study, we show novel DNA motifs that promote single nucleotide polymorphism (SNP) formation and are conserved among exons, introns, and intergenic DNA from mice (Sanger Mouse Genomes Project), human genes (1000 Genomes), and tumor-specific somatic mutations (data from TCGA). We further characterize SNPs likely to be very recent in origin (i.e., formed in otherwise congenic mice) and show enrichment for both synonymous and parallel DNA variants occurring under circumstances not attributable to purifying selection. The findings provide insight regarding SNP contextual bias and eukaryotic codon usage as strategies that favor long-term exonic stability. The study also furnishes new information concerning rates of murine genomic evolution and features of DNA mutagenesis (at the time of SNP formation) that should be viewed as "adaptive."

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