Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii | Zendy

Liangkun Long | Zendy; Zhen Liu | Zendy; Chun-Ying Deng | Zendy; Chuanhua Li | Zendy; Liangliang Wu | Zendy; Beiwei Hou | Zendy; Qunying Lin | Zendy

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Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii

Author(s) -

Liangkun Long,

Zhen Liu,

Chun-Ying Deng,

Chuanhua Li,

Liangliang Wu,

Beiwei Hou,

Qunying Lin

Publication year - 2022

Publication title -

genome biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.702

H-Index - 74

ISSN - 1759-6653

DOI - 10.1093/gbe/evac033

Subject(s) - biology , fungus , transcriptome , gene , mycelium , illumina dye sequencing , genome , whole genome sequencing , sequence assembly , in silico , dna sequencing , genetics , sequence analysis , computational biology , botany , gene expression

The filamentous fungus Keithomyces neogunnii can infect the larvae of Lepidoptera (Hepialus sp.) and form an insect–fungi complex, which is utilized as an important traditional Chinese medicine. As a valuable medicinal fungus, K. neogunnii produces diverse bioactive substances (e.g., polysaccharide, vitamins, cordycepic acid, and adenosine) under cultivation conditions. Herein, we report the first high-quality genome of the K. neogunnii single-spore isolate Cg7.2a using single-molecule real-time sequencing technology in combination with Illumina sequencing. The assembled genome was 32.6 Mb in size, containing 8,641 predicted genes and having a GC content of 52.16%. RNA sequencing analysis revealed the maximum number of differentially expressed genes in the fungus during the stroma formation stage compared with those during the mycelium stage. These data are valuable to enhance our understanding of the biology, development, evolution, and physiological metabolism of K. neogunnii.

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