Open AccessA multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric-cancer patients
Author(s) -
Yinjie Zhang,
Yang Yang,
Qing Wei,
Ting Xu,
Xiaotian Zhang,
Jing Gao,
Siyi Tan,
Baorui Liu,
Jingdong Zhang,
Xiaobing Chen,
Zhaojie Wang,
Meng Qiu,
Xin Wang,
Lin Shen,
Xicheng Wang
Publication year - 2021
Publication title -
gastroenterology report
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 26
eISSN - 2052-0034
pISSN - 2304-1412
DOI - 10.1093/gastro/goab020
Subject(s) - mutyh , medicine , genetics , germline , cancer , chek2 , sanger sequencing , germline mutation , proband , genetic testing , palb2 , genetic predisposition , population , gene , mutation , biology , environmental health
Approximately 10% of patients with gastric cancer (GC) have a genetic predisposition toward the disease. However, there is scant knowledge regarding germline mutations in predisposing genes in the Chinese GC population. This study aimed to determine the spectrum and distribution of predisposing gene mutations among Chinese GC patients known to have hereditary high-risk factors for cancer.
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