The tumor immune microenvironment transcriptomic subtypes of colorectal cancer for prognosis and development of precise immunotherapy | Zendy

Yunqiang Tang | Zendy; Tufeng Chen | Zendy; Yan Zhang | Zendy; Xiaochen Zhao | Zendy; Yuzi Zhang | Zendy; Guoqiang Wang | Zendy; Mengli Huang | Zendy; Shangli Cai | Zendy; Jing Zhao | Zendy; Bo Wei | Zendy; Jun Huang | Zendy

Open Access

The tumor immune microenvironment transcriptomic subtypes of colorectal cancer for prognosis and development of precise immunotherapy

Author(s) -

Yunqiang Tang,

Tufeng Chen,

Yan Zhang,

Xiaochen Zhao,

Yuzi Zhang,

Guoqiang Wang,

Mengli Huang,

Shangli Cai,

Jing Zhao,

Bo Wei,

Jun Huang

Publication year - 2020

Publication title -

gastroenterology report

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.934

H-Index - 26

eISSN - 2052-0034

pISSN - 2304-1412

DOI - 10.1093/gastro/goaa045

Subject(s) - medicine , colorectal cancer , immunotherapy , immune system , tumor microenvironment , cancer immunotherapy , transcriptome , tumor immunology , immune escape , bench to bedside , cancer research , cancer , oncology , immunology , gene , medical physics , biology , gene expression , biochemistry

Biomarkers based on immune context may guide prognosis prediction. T-cell inactivation, exclusion, or dysfunction could cause unfavorable tumor microenvironments, which affect immunotherapy and prognosis. However, none of the immuno-biomarkers reported to date can differentiate colorectal-cancer (CRC) patients. Thus, we aimed to classify CRC patients according to the levels of T-cell activation, exclusion, and dysfunction in the tumor microenvironment.

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