Beyond the bulk: disclosing the life of single microbial cells | Zendy

Katrin Rosenthal | Zendy; Verena Oehling | Zendy; Christian Dusny | Zendy; Andreas Schmid | Zendy

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Beyond the bulk: disclosing the life of single microbial cells

Author(s) -

Katrin Rosenthal,

Verena Oehling,

Christian Dusny,

Andreas Schmid

Publication year - 2017

Publication title -

fems microbiology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.91

H-Index - 212

eISSN - 1574-6976

pISSN - 0168-6445

DOI - 10.1093/femsre/fux044

Subject(s) - biology , single cell analysis , population , biochemical engineering , data science , computational biology , nanotechnology , cell , computer science , engineering , genetics , demography , materials science , sociology

Microbial single cell analysis has led to discoveries that are beyond what can be resolved with population-based studies. It provides a pristine view of the mechanisms that organize cellular physiology, unbiased by population heterogeneity or uncontrollable environmental impacts. A holistic description of cellular functions at the single cell level requires analytical concepts beyond the miniaturization of existing technologies, defined but uncontrolled by the biological system itself. This review provides an overview of the latest advances in single cell technologies and demonstrates their potential. Opportunities and limitations of single cell microbiology are discussed using selected application-related examples.

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