Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci | Zendy

Débora C. CoraçaHuber | Zendy; Stefanie Dichtl | Zendy; Stephan Steixner | Zendy; Michaël Nogler | Zendy; Günter Weiß | Zendy

Open Access

Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci

Author(s) -

Débora C. CoraçaHuber,

Stefanie Dichtl,

Stephan Steixner,

Michaël Nogler,

Günter Weiß

Publication year - 2018

Publication title -

pathogens and disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.983

H-Index - 105

ISSN - 2049-632X

DOI - 10.1093/femspd/fty052

Subject(s) - microbiology and biotechnology , antimicrobial , coagulase , antibiotics , biofilm , chelation , staphylococcus , chemistry , biology , staphylococcus aureus , bacteria , genetics , organic chemistry

The ability of certain bacteria to form biofilms underlies their capacity to cause medical device-associated infections. Most bacteria need the metal iron for their proliferation but also to form biofilms. The aim of this in vitro study was to investigate whether iron restriction upon application of the iron chelator deferiprone (DFP) impacts on bacterial biofilm formation and whether such an intervention can exert synergistic effects towards the antibacterial activity of three antibiotic compounds against coagulase-negative staphylococci (CNS) residing on titanium plates.

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