The CRISPR-Cas system in Enterobacteriaceae | Zendy

Liliana Medina-Aparicio | Zendy; Sonia DávilaRamos | Zendy; Javier E. Rebollar-Flores | Zendy; Edmundo Calva | Zendy; Ismael Hernández-Lucas | Zendy

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The CRISPR-Cas system in Enterobacteriaceae

Author(s) -

Liliana Medina-Aparicio,

Sonia DávilaRamos,

Javier E. Rebollar-Flores,

Edmundo Calva,

Ismael Hernández-Lucas

Publication year - 2018

Publication title -

pathogens and disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.983

H-Index - 105

ISSN - 2049-632X

DOI - 10.1093/femspd/fty002

Subject(s) - crispr , biology , enterobacteriaceae , palindrome , computational biology , genome editing , genome , genetics , dna , microbiology and biotechnology , gene , escherichia coli

In nature, microorganisms are constantly exposed to multiple viral infections and thus have developed many strategies to survive phage attack and invasion by foreign DNA. One of such strategies is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological system. This defense mechanism is widespread in prokaryotes including several families such as Enterobacteriaceae. Much knowledge about the CRISPR-Cas system has been generated, including its biological functions, transcriptional regulation, distribution, utility as a molecular marker and as a tool for specific genome editing. This review focuses on these aspects and describes the state of the art of the CRISPR-Cas system in the Enterobacteriaceae bacterial family.

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