Open AccessSphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection
Author(s) -
Irina V. Tiper,
James E. East,
Priyanka B. Subrahmanyam,
Tonya J. Webb
Publication year - 2016
Publication title -
pathogens and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.983
H-Index - 105
ISSN - 2049-632X
DOI - 10.1093/femspd/ftw063
Subject(s) - sphingosine , sphingosine 1 phosphate , lipid signaling , g protein coupled receptor , inflammation , sphingosine 1 phosphate receptor , microbiology and biotechnology , biology , receptor , signal transduction , context (archaeology) , sphingosine kinase 1 , ceramide , sphingolipid , angiogenesis , s1pr1 , sphingosine kinase , immunology , cancer research , biochemistry , apoptosis , vascular endothelial growth factor a , paleontology , vascular endothelial growth factor , vegf receptors
Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P1-5). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed.
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