Open AccessOmics-based comparative analysis of putative mobile genetic elements in Lactococcus lactis
Author(s) -
Joakim M. Andersen,
Christine Møller Pedersen,
Claus Heiner BangBerthelsen
Publication year - 2019
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1093/femsle/fnz102
Subject(s) - lactococcus lactis , biology , mobile genetic elements , genomics , genetics , prophage , comparative genomics , functional genomics , computational biology , genetic variation , genome , gene , bacteria , bacteriophage , lactic acid , escherichia coli
Lactococcus lactis is globally used in food fermentation. Genomics is useful to investigate speciation and differential occurrence of (un)desired gene functions, often related to mobile DNA. This study investigates L. lactis for putative chromosomal mobile genetic elements through comparative genomics, and analyses how they contribute to chromosomal variation at strain level. Our work identified 95 loci that may range over 10% of the chromosome size when including prophages, and the loci display a marked differential occurrence in the analysed strains. Analysis of differential transcriptomics data revealed how mobile genetic elements may impact the host physiology in response to conditional changes. This insight in the genetic variation of mobile genetic elements in L. lactis holds potential to further identify important functions related to food and biotechnology applications within this important species.
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