Droplet-based microfluidics as a future tool for strain improvement in lactic acid bacteria | Zendy

Jun Chen | Zendy; Mike Vestergaard | Zendy; Jing Shen | Zendy; Christian Solem | Zendy; Martin Dufva | Zendy; Peter Ruhdal Jensen | Zendy

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Droplet-based microfluidics as a future tool for strain improvement in lactic acid bacteria

Author(s) -

Jun Chen,

Mike Vestergaard,

Jing Shen,

Christian Solem,

Martin Dufva,

Peter Ruhdal Jensen

Publication year - 2018

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fny258

Subject(s) - microfluidics , bacteria , mutagenesis , lactic acid , strain (injury) , high throughput screening , fermentation , biochemical engineering , microbiology and biotechnology , nanotechnology , biology , computational biology , mutant , food science , materials science , bioinformatics , biochemistry , genetics , engineering , anatomy , gene

Strain development is frequently used to improve the performance and functionality of industrially important microbes. As traditional mutagenesis screen is especially utilized by the food industry to improve strains used in food fermentation, high-throughput and cost-effective screening tools are important in mutant selection. The emerging droplet-based microfluidics technology miniaturizes the volume for cell cultivation and phenotype interrogation down to the picoliter scales, which facilitates screening of microbes for improved phenotypical properties tremendously. In this mini review, we present recent application of the droplet-based microfluidics in microbial strain improvement with a focus on its potential use in the screening of lactic acid bacteria.

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