Type I secretion system—it takes three and a substrate | Zendy

Kerstin Kanberg | Zendy; Olivia Spitz | Zendy; Isabelle N. Erenburg | Zendy; Tobias Beer | Zendy; Lutz Schmitt | Zendy

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Type I secretion system—it takes three and a substrate

Author(s) -

Kerstin Kanberg,

Olivia Spitz,

Isabelle N. Erenburg,

Tobias Beer,

Lutz Schmitt

Publication year - 2018

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fny094

Subject(s) - periplasmic space , secretion , bacterial outer membrane , transport protein , virulence , secretory protein , membrane transport protein , microbiology and biotechnology , biology , type vi secretion system , cytosol , inner membrane , membrane protein , biochemistry , membrane , escherichia coli , gene , enzyme

Type I secretion systems are widespread in Gram-negative bacteria and mediate the one-step translocation of a large variety of proteins serving for diverse purposes, including nutrient acquisition or bacterial virulence. Common to most substrates of type I secretion systems is the presence of a C-terminal secretion sequence that is not cleaved during or after translocation. Furthermore, these protein secretion nanomachineries are always composed of an ABC transporter, a membrane fusion protein, both located in the inner bacterial membrane, and a protein of the outer membrane. These three membrane proteins transiently form a 'tunnel channel' across the periplasmic space in the presence of the substrate. Here we summarize the recent findings with respect to structure, function and application of type I secretion systems.

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