Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance | Zendy

Shawn T. Clark | Zendy; David S. Guttman | Zendy; David Hwang | Zendy

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Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance

Author(s) -

Shawn T. Clark,

David S. Guttman,

David Hwang

Publication year - 2018

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fny026

Subject(s) - pseudomonas aeruginosa , cystic fibrosis , antibiotic resistance , biology , antibiotics , microbiology and biotechnology , antimicrobial , genetic diversity , bacteria , genetics , medicine , population , environmental health

The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in understanding within-host diversity and antimicrobial resistance in P. aeruginosa populations from the lower airways of individuals with the fatal genetic disease cystic fibrosis and the potential impacts that this diversity may have on detecting and interpreting antimicrobial susceptibility within these populations.

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