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Previous epidemiologic studies have demonstrated an inverse association between Helicobacter pylori infection and the frequency of allergic asthma. The neutrophil-activating protein (NAP) of H. pylori has been identified as a modulator possessing anti-Th2 inflammation activity. Here, we sought to determine whether systemic or mucosal pre-administration of recombinant H. pylori NAP (rNAP) could prevent ovalbumin (OVA)-induced allergic asthma in mice.

fems microbiology letters

Systemic and mucosal pre-administration of recombinant<i>Helicobacter pylori</i>neutrophil-activating protein prevents ovalbumin-induced allergic asthma in mice

Systemic and mucosal pre-administration of recombinantHelicobacter pylorineutrophil-activating protein prevents ovalbumin-induced allergic asthma in mice