Systemic and mucosal pre-administration of recombinantHelicobacter pylorineutrophil-activating protein prevents ovalbumin-induced allergic asthma in mice | Zendy

Shuai Zhou | Zendy; Yanmei Huang | Zendy; Bingshao Liang | Zendy; Hui Dong | Zendy; Shuwen Yao | Zendy; Yinshuang Chen | Zendy; Yongqiang Xie | Zendy; Yan Long | Zendy; Sitang Gong | Zendy; Zhenwen Zhou | Zendy

Open Access

Systemic and mucosal pre-administration of recombinantHelicobacter pylorineutrophil-activating protein prevents ovalbumin-induced allergic asthma in mice

Author(s) -

Shuai Zhou,

Yanmei Huang,

Bingshao Liang,

Hui Dong,

Shuwen Yao,

Yinshuang Chen,

Yongqiang Xie,

Yan Long,

Sitang Gong,

Zhenwen Zhou

Publication year - 2017

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fnw288

Subject(s) - ovalbumin , helicobacter pylori , immunology , recombinant dna , medicine , asthma , microbiology and biotechnology , chemistry , biology , immune system , gastroenterology , biochemistry , gene

Previous epidemiologic studies have demonstrated an inverse association between Helicobacter pylori infection and the frequency of allergic asthma. The neutrophil-activating protein (NAP) of H. pylori has been identified as a modulator possessing anti-Th2 inflammation activity. Here, we sought to determine whether systemic or mucosal pre-administration of recombinant H. pylori NAP (rNAP) could prevent ovalbumin (OVA)-induced allergic asthma in mice.

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