Draft genome sequence ofStreptomycessp. TP-A0882 reveals putative butyrolactol biosynthetic pathway | Zendy

Hisayuki Komaki | Zendy; Natsuko Ichikawa | Zendy; Akira Hosoyama | Zendy; Nobuyuki Fujita | Zendy; Yasuhiro Igarashi | Zendy

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Draft genome sequence ofStreptomycessp. TP-A0882 reveals putative butyrolactol biosynthetic pathway

Author(s) -

Hisayuki Komaki,

Natsuko Ichikawa,

Akira Hosoyama,

Nobuyuki Fujita,

Yasuhiro Igarashi

Publication year - 2015

Publication title -

fems microbiology letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fnv155

Subject(s) - polyketide , gene cluster , nonribosomal peptide , polyketide synthase , biology , genome , gene , streptomyces , genetics , whole genome sequencing , biosynthesis , bacteria

We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide.

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