Antimicrobial and biofilm-disrupting nanostructured TiO2 coating demonstrating photoactivity and dark activity | Zendy

Alibe Wasa | Zendy; Johann G. Land | Zendy; Rukmini Gorthy | Zendy; Susan Krumdieck | Zendy; Catherine M. Bishop | Zendy; William Godsoe | Zendy; Jack A. Heinemann | Zendy

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Antimicrobial and biofilm-disrupting nanostructured TiO2 coating demonstrating photoactivity and dark activity

Author(s) -

Alibe Wasa,

Johann G. Land,

Rukmini Gorthy,

Susan Krumdieck,

Catherine M. Bishop,

William Godsoe,

Jack A. Heinemann

Publication year - 2021

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fnab039

Subject(s) - biofilm , antimicrobial , pseudomonas aeruginosa , coating , inert , microbiology and biotechnology , staphylococcus aureus , materials science , microorganism , escherichia coli , biofouling , nanotechnology , bacteria , chemistry , biology , organic chemistry , biochemistry , genetics , membrane , gene

Antimicrobial materials are tools used to reduce the transmission of infectious microorganisms. Photo-illuminated titania (TiO2) is a known antimicrobial material. Used as a coating on door handles and similar surfaces, it may reduce viability and colonization by pathogens and limit their spread. We tested the survival of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Saccharomyces cerevisiae on a nano-structured TiO2-based thin film, called ‘NsARC’, and on stainless steel under a variety of light wavelengths and intensities. There was significantly less survival (P <0.001) of all the organisms tested on NsARC compared to inert uncoated stainless steel under all conditions. NsARC was active in the dark and possible mechanisms for this are suggested. NsARC inhibited biofilm formation as confirmed by scanning electron microscopy. These results suggest that NsARC can be used as a self-cleaning and self-sterilizing antimicrobial surface coating for the prevention and reduction in the spread of potentially infectious microbes.

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