Construction of artificial membrane transport metabolons – an emerging strategy in metabolic engineering | Zendy

Mislav Oreb | Zendy

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Construction of artificial membrane transport metabolons – an emerging strategy in metabolic engineering

Author(s) -

Mislav Oreb

Publication year - 2020

Publication title -

fems microbiology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.899

H-Index - 151

eISSN - 1574-6968

pISSN - 0378-1097

DOI - 10.1093/femsle/fnaa027

Subject(s) - membrane transport , membrane transport protein , synthetic biology , membrane , metabolic engineering , transporter , substrate (aquarium) , biochemical engineering , metabolic pathway , coupling (piping) , chemistry , enzyme , biochemistry , biophysics , computational biology , biology , membrane protein , engineering , ecology , gene , mechanical engineering

The term ‘membrane transport metabolon’ refers to the physical association of membrane transporters with enzymes that metabolize the transported substrates. In naturally evolved systems, physiological relevance of coupling transport with sequential enzymatic reactions resides, for instance, in faster turnover rates, protection of substrates from competing pathways or shielding the cellular environment from toxic compounds. Such underlying principles offer attractive possibilities for metabolic engineering approaches and concepts for constructing artificial transporter-enzyme complexes are recently being developed. In this minireview, the modes of substrate channeling across biological membranes and design principles for artificial transport metabolons are discussed.

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