Mineralocorticoid receptor antagonists and atrial fibrillation: a meta-analysis | Zendy

Tong Liu | Zendy; Panagiotis Korantzopoulos | Zendy; Qingmiao Shao | Zendy; Zhiwei Zhang | Zendy; Κonstantinos P. Letsas | Zendy; Guangping Li | Zendy

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Mineralocorticoid receptor antagonists and atrial fibrillation: a meta-analysis

Author(s) -

Tong Liu,

Panagiotis Korantzopoulos,

Qingmiao Shao,

Zhiwei Zhang,

Κonstantinos P. Letsas,

Guangping Li

Publication year - 2015

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/euv366

Subject(s) - atrial fibrillation , mineralocorticoid receptor , medicine , mineralocorticoid , cardiology , receptor

Aldosterone has been implicated in atrial remodelling representing a potential target for upstream therapies. Accumulating evidence suggests that mineralocorticoid receptor blockade may have favourable effects on atrial fibrillation (AF) development, although some controversial results have been published. We, therefore, conducted a meta-analysis of randomized clinical trials (RCTs) and observational studies in order to examine the protective role of mineralocorticoid receptor antagonists (MRAs) on AF.

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