Effects of premature anodal stimulations on cardiac transmembrane potential and intracellular calcium distributions computed by anisotropic Bidomain models | Zendy

Piero Colli Franzone | Zendy; Luca F. Pavarino | Zendy; Simone Scacchi | Zendy

Open Access

Effects of premature anodal stimulations on cardiac transmembrane potential and intracellular calcium distributions computed by anisotropic Bidomain models

Author(s) -

Piero Colli Franzone,

Luca F. Pavarino,

Simone Scacchi

Publication year - 2014

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/euu010

Subject(s) - bidomain model , defibrillation , phenomenological model , wavefront , calcium in biology , anode , optical mapping , cardiac electrophysiology , electrophysiology , physics , calcium , biomedical engineering , biophysics , neuroscience , medicine , electrode , optics , biology , quantum mechanics

Cardiac unipolar electrode stimulations induce a particular structure of the transmembrane potential distribution (Vm), called virtual electrode polarization (VEP), which plays an important role in the mechanisms of cardiac excitation, reentry induction, and ventricular defibrillation. Recent experimental studies, based on the optical mapping techniques, have shown that premature stimulations also induce significant changes in the intracellular calcium (Cai) spatial distribution. The aim of this work is to investigate and compare by means of numerical simulations the morphology of the Vm and Cai patterns, generated by applying an S1-S2 stimulation protocol with a premature S2 anodal pulse.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research