Arrhythmic potency of human ether-à-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes | Zendy

Axel Loewe | Zendy; Mathias Wilhelms | Zendy; Fathima Fischer | Zendy; Eberhard P. Scholz | Zendy; Olaf Dössel | Zendy; Gunnar Seemann | Zendy

Open Access

Arrhythmic potency of human ether-à-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes

Author(s) -

Axel Loewe,

Mathias Wilhelms,

Fathima Fischer,

Eberhard P. Scholz,

Olaf Dössel,

Gunnar Seemann

Publication year - 2014

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/eut375

Subject(s) - herg , medicine , missense mutation , atrial fibrillation , mechanism (biology) , mutation , potency , gene , pharmacology , cardiology , in vitro , genetics , potassium channel , philosophy , epistemology , biology

Human ether-à-go-go-related gene (hERG) missense mutations N588K and L532P are both associated with atrial fibrillation (AF). However, the underlying gain-of-function mechanism is different. The aim of this computational study is to assess and understand the arrhythmogenic mechanisms of these genetic disorders on the cellular and tissue level as a basis for the improvement of therapeutic strategies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research