Open AccessCommon SCN10A variants modulate PR interval and heart rate response during atrial fibrillation
Author(s) -
Jessica Delaney,
Raafia Muhammad,
Yaping Shi,
Jonathan S. Schildcrout,
Marcia Blair,
Laura Short,
Dan M. Roden,
Dawood Darbar
Publication year - 2013
Publication title -
europace
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 102
eISSN - 1532-2092
pISSN - 1099-5129
DOI - 10.1093/europace/eut278
Subject(s) - medicine , atrial fibrillation , cardiology , sinus rhythm , heart rate , heart failure , sick sinus syndrome , pr interval , cohort , single nucleotide polymorphism , genotype , blood pressure , genetics , gene , biology
SCN10A encodes the sodium channel Nav1.8 implicated by genome-wide association studies as a modulator of atrioventricular conduction (PR interval). In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association between common variants in SCN10A and both the PR interval during normal sinus rhythm and the heart rate response during AF.