Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation | Zendy

Niels Voigt | Zendy; Dobromir Dobrev | Zendy

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Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation

Author(s) -

Niels Voigt,

Dobromir Dobrev

Publication year - 2012

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/eus282

Subject(s) - medicine , atrial fibrillation , pathophysiology , ectopic expression , cardiology , intracellular , mechanism (biology) , calcium in biology , clinical significance , bioinformatics , calcium , biochemistry , chemistry , philosophy , epistemology , biology , gene , microbiology and biotechnology

Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with increased morbidity and mortality. Current drugs for AF treatment have limited efficacy and a substantial risk of proarrhythmic side effects, making novel drug development critical. Emerging evidence suggests that abnormal intracellular calcium (Ca(2+)) signalling is a key contributor to ectopic (triggered) electrical activity in human AF. Accordingly, atrial Ca(2+)-handling abnormalities underlying ectopic activity may constitute novel mechanism-based therapeutic approaches to treat AF. This article reviews the recent evidence for a role of cellular ectopic activity in human AF pathophysiology, discusses the molecular mechanisms underlying triggered activity in human atrial myocytes, and considers their relevance to the design of novel therapeutic options.

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