The role of action potential alternans in the initiation of atrial fibrillation in humans: a review and future directions | Zendy

Michael R. Franz | Zendy; Sameer Jamal | Zendy; Sanjiv M. Narayan | Zendy

Open Access

The role of action potential alternans in the initiation of atrial fibrillation in humans: a review and future directions

Author(s) -

Michael R. Franz,

Sameer Jamal,

Sanjiv M. Narayan

Publication year - 2012

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/eus273

Subject(s) - medicine , atrial fibrillation , maladaptation , cardiology , pathophysiology , atrial action potential , electrophysiology , repolarization , psychiatry

This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.

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