Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch | Zendy

Marjorie Letitia Hubbard | Zendy; Craig S. Henriquez | Zendy

Open Access

Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch

Author(s) -

Marjorie Letitia Hubbard,

Craig S. Henriquez

Publication year - 2012

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/eus267

Subject(s) - medicine , intracellular , thermal conduction , block (permutation group theory) , distribution (mathematics) , heart block , biophysics , cardiology , microbiology and biotechnology , electrocardiography , composite material , biology , mathematical analysis , materials science , geometry , mathematics

Reentrant activity in the heart is often correlated with heterogeneity in both the intracellular structure and the interstitial structure surrounding cells; however, the combined effect of cardiac microstructure and interstitial resistivity in regions of source-load mismatch is largely unknown. The aim of this study was to investigate how microstructural variations in cell arrangement and increased interstitial resistivity influence the spatial distribution of conduction delays and block in poorly coupled regions of tissue.

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