Open AccessBradycardic onset of spiral wave re-entry: structural substrates
Author(s) -
Christian W. Zemlin,
Arkady M. Pertsov
Publication year - 2007
Publication title -
ep europace
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 102
eISSN - 1532-2092
pISSN - 1099-5129
DOI - 10.1093/europace/eum205
Subject(s) - medicine , spiral wave , spiral (railway) , coupling (piping) , stimulation , bradycardia , biophysics , heart rate , mechanical engineering , mathematical analysis , mathematics , blood pressure , engineering , biology
The least understood aspect of re-entrant cardiac arrhythmias is how they start spontaneously. The known mechanisms for re-entry induction involve the application of premature electrical stimuli or rapid pacing, whereas in a clinical setting, re-entry often occurs at normal heart rates. Here, we propose a physiological mechanism of re-entry onset at normal and slow heart rates, which is based on structurally determined heterogeneities.
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